Assay Detail
Binding
CHEMBL3362239
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Inhibition of human PDE4B
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of triazines as selective PDE4B versus PDE4D inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.19 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3315271 | — | — | 1 | 7.92 |
| CHEMBL3315265 | — | — | 1 | 7.34 |
| CHEMBL3315273 | — | — | 1 | 7.16 |
| CHEMBL3315272 | — | — | 1 | 6.90 |
| CHEMBL3315266 | — | — | 1 | 6.87 |
| CHEMBL3315267 | — | — | 1 | 6.87 |
| CHEMBL3313945 | — | — | 1 | 6.78 |
| CHEMBL3315263 | — | — | 1 | 6.66 |
| CHEMBL3315251 | — | — | 1 | 6.62 |
| CHEMBL3315270 | — | — | 1 | 6.62 |
| CHEMBL3315250 | — | — | 1 | 6.60 |
| CHEMBL3315261 | — | — | 1 | 6.58 |
| CHEMBL3315248 | — | — | 1 | 6.42 |
| CHEMBL3315274 | — | — | 1 | 6.40 |
| CHEMBL3315269 | — | — | 1 | 6.11 |
| CHEMBL3315258 | — | — | 1 | 6.07 |
| CHEMBL3315275 | — | — | 1 | 5.96 |
| CHEMBL3315246 | — | — | 1 | 5.89 |
| CHEMBL3315262 | — | — | 1 | 5.86 |
| CHEMBL3315254 | — | — | 1 | 5.84 |
| CHEMBL3315255 | — | — | 1 | 5.84 |
| CHEMBL3315276 | — | — | 1 | 5.80 |
| CHEMBL3315259 | — | — | 1 | 5.73 |
| CHEMBL3315247 | — | — | 1 | 5.71 |
| CHEMBL3315257 | — | — | 1 | 5.64 |
| CHEMBL3315249 | — | — | 1 | 5.61 |
| CHEMBL3315256 | — | — | 1 | 5.56 |
| CHEMBL3315252 | — | — | 1 | 5.42 |
| CHEMBL3315260 | — | — | 1 | 5.39 |
| CHEMBL3315264 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3315271 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3315265 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3315273 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3315272 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3315266 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL3315267 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL3313945 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL3315263 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3315251 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL3315270 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL3315250 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL3315261 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL3315248 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL3315274 | — | IC50 | = | 402.0 | nM | 6.40 |
| CHEMBL3315269 | — | IC50 | = | 781.0 | nM | 6.11 |
| CHEMBL3315258 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL3315275 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3315246 | — | IC50 | = | 1287.0 | nM | 5.89 |
| CHEMBL3315262 | — | IC50 | = | 1394.0 | nM | 5.86 |
| CHEMBL3315254 | — | IC50 | = | 1437.0 | nM | 5.84 |
| CHEMBL3315255 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL3315276 | — | IC50 | = | 1574.0 | nM | 5.80 |
| CHEMBL3315259 | — | IC50 | = | 1862.0 | nM | 5.73 |
| CHEMBL3315247 | — | IC50 | = | 1945.0 | nM | 5.71 |
| CHEMBL3315257 | — | IC50 | = | 2282.0 | nM | 5.64 |
| CHEMBL3315249 | — | IC50 | = | 2447.0 | nM | 5.61 |
| CHEMBL3315256 | — | IC50 | = | 2777.0 | nM | 5.56 |
| CHEMBL3315252 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL3315260 | — | IC50 | = | 4048.0 | nM | 5.39 |
| CHEMBL3315264 | — | IC50 | = | 8815.0 | nM | 5.05 |
| CHEMBL3315253 | — | IC50 | = | 18755.0 | nM | 4.73 |
| CHEMBL3315268 | — | IC50 | - | — | - |