Assay Detail
Binding
CHEMBL3362706
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Inhibition of wild type HIV1 reverse transcriptase assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.34 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3327156 | — | — | 1 | 5.96 |
| CHEMBL3327148 | — | — | 1 | 5.82 |
| CHEMBL3327153 | — | — | 1 | 5.75 |
| CHEMBL3327158 | — | — | 1 | 5.62 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | 5.60 |
| CHEMBL3327159 | — | — | 1 | 5.15 |
| CHEMBL3327160 | — | — | 1 | 5.08 |
| CHEMBL3327155 | — | — | 1 | 5.05 |
| CHEMBL3327152 | — | — | 1 | 5.00 |
| CHEMBL3357472 | — | — | 1 | 4.98 |
| CHEMBL3327157 | — | — | 1 | 4.70 |
| CHEMBL3327154 | — | — | 1 | - |
| CHEMBL3327150 | — | — | 1 | - |
| CHEMBL3327149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3327156 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3327148 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3327153 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3327158 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL666 | FOSCARNET | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3327159 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3327160 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3327155 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3327152 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3357472 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL3327157 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3327154 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3327150 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3327149 | — | IC50 | > | 50000.0 | nM | - |