Assay Detail
Functional
CHEMBL3362907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 ROD acutely infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenic effect after 5 days by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.60 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125002 | — | — | 1 | 6.60 |
| CHEMBL3327279 | — | — | 1 | - |
| CHEMBL3327280 | — | — | 1 | - |
| CHEMBL3327281 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125002 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3327279 | — | EC50 | > | 23500.0 | nM | - |
| CHEMBL3327280 | — | EC50 | > | 25700.0 | nM | - |
| CHEMBL3327281 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 15000.0 | nM | - |