Assay Detail
Functional
CHEMBL3363135
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Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.79 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 7.40 |
| CHEMBL8320 | BENZOQUINONE | — | 1 | 5.59 |
| CHEMBL3331546 | — | — | 1 | 5.57 |
| CHEMBL3331547 | — | — | 1 | 5.23 |
| CHEMBL3331545 | — | — | 1 | 5.18 |
| CHEMBL445332 | SALVINORIN A | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL8320 | BENZOQUINONE | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL3331546 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3331547 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL3331545 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL445332 | SALVINORIN A | IC50 | > | 100000.0 | nM | - |