Assay Detail
Binding
CHEMBL3363249
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Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate by spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.92 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3322231 | — | — | 1 | 8.69 |
| CHEMBL292314 | — | — | 1 | 8.23 |
| CHEMBL3322234 | — | — | 1 | 7.85 |
| CHEMBL3322233 | — | — | 1 | 7.85 |
| CHEMBL1196204 | — | — | 1 | 7.71 |
| CHEMBL3122167 | — | — | 1 | 7.19 |
| CHEMBL1194313 | — | — | 1 | - |
| CHEMBL3322232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3322231 | — | IC50 | = | 2.06 | nM | 8.69 |
| CHEMBL292314 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3322234 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL3322233 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL1196204 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL3122167 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1194313 | — | IC50 | - | — | - | |
| CHEMBL3322232 | — | IC50 | = | 0.006 | nM | - |