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Assay Detail

CHEMBL3363288

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]1-Iodo-4-((4-methoxyphenoxy)methyl)benzene from amyloid beta42 (unknown origin) after 3 hrs by gamma counting
ChEMBL ↗
48
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Radioiodinated benzyloxybenzene derivatives: a class of flexible ligands target to β-amyloid plaques in Alzheimer's brains.
Yang Y, Cui M, Zhang X, Dai J, Zhang Z, Lin C, Guo Y, Liu B.
J Med Chem (2014) 57 : 6030 -6042
PubMed 24936678 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 48 6.74 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3314330 — — 2 7.92
CHEMBL3314340 — — 2 7.75
CHEMBL3314329 — — 2 7.73
CHEMBL3314331 — — 2 7.66
CHEMBL3314322 — — 2 7.61
CHEMBL78012 — — 2 7.49
CHEMBL93124 PITTSBURGH COMPOUND B UNLABELLED 2.0 2 7.41
CHEMBL3314337 — — 2 7.32
CHEMBL3314342 — — 2 7.31
CHEMBL3314332 — — 2 7.10
CHEMBL3314328 — — 2 6.97
CHEMBL3314325 — — 2 6.95
CHEMBL3314333 — — 2 6.93
CHEMBL3314323 — — 2 6.88
CHEMBL3314326 — — 2 6.41
CHEMBL3314334 — — 2 6.39
CHEMBL3314343 — — 2 6.28
CHEMBL3314338 — — 2 6.23
CHEMBL3314341 — — 2 6.05
CHEMBL3314336 — — 2 5.99
CHEMBL3314335 — — 2 5.81
CHEMBL3314327 — — 2 5.55
CHEMBL3314324 — — 2 5.29
CHEMBL3314339 — — 2 4.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3314330 — Ki = 12.0 nM 7.92
CHEMBL3314330 — Ki = 12.02 nM 7.92
CHEMBL3314340 — Ki = 17.6 nM 7.75
CHEMBL3314340 — Ki = 17.78 nM 7.75
CHEMBL3314329 — Ki = 18.62 nM 7.73
CHEMBL3314329 — Ki = 18.8 nM 7.73
CHEMBL3314331 — Ki = 21.88 nM 7.66
CHEMBL3314331 — Ki = 21.9 nM 7.66
CHEMBL3314322 — Ki = 24.3 nM 7.61
CHEMBL3314322 — Ki = 24.55 nM 7.61
CHEMBL78012 — Ki = 32.36 nM 7.49
CHEMBL78012 — Ki = 32.2 nM 7.49
CHEMBL93124 PITTSBURGH COMPOUND B UNLABELLED Ki = 38.8 nM 7.41
CHEMBL93124 PITTSBURGH COMPOUND B UNLABELLED Ki = 38.9 nM 7.41
CHEMBL3314337 — Ki = 48.2 nM 7.32
CHEMBL3314337 — Ki = 47.86 nM 7.32
CHEMBL3314342 — Ki = 48.98 nM 7.31
CHEMBL3314342 — Ki = 49.4 nM 7.31
CHEMBL3314332 — Ki = 79.43 nM 7.10
CHEMBL3314332 — Ki = 79.4 nM 7.10
CHEMBL3314328 — Ki = 107.1 nM 6.97
CHEMBL3314328 — Ki = 107.15 nM 6.97
CHEMBL3314325 — Ki = 113.4 nM 6.95
CHEMBL3314325 — Ki = 112.2 nM 6.95
CHEMBL3314333 — Ki = 117.6 nM 6.93
CHEMBL3314333 — Ki = 117.49 nM 6.93
CHEMBL3314323 — Ki = 131.83 nM 6.88
CHEMBL3314323 — Ki = 130.6 nM 6.88
CHEMBL3314326 — Ki = 389.05 nM 6.41
CHEMBL3314326 — Ki = 385.6 nM 6.41
CHEMBL3314334 — Ki = 407.38 nM 6.39
CHEMBL3314334 — Ki = 409.2 nM 6.39
CHEMBL3314343 — Ki = 524.81 nM 6.28
CHEMBL3314343 — Ki = 530.2 nM 6.28
CHEMBL3314338 — Ki = 593.6 nM 6.23
CHEMBL3314338 — Ki = 588.84 nM 6.23
CHEMBL3314341 — Ki = 894.2 nM 6.05
CHEMBL3314341 — Ki = 891.25 nM 6.05
CHEMBL3314336 — Ki = 1028.0 nM 5.99
CHEMBL3314336 — Ki = 1023.29 nM 5.99
CHEMBL3314335 — Ki = 1534.7 nM 5.81
CHEMBL3314335 — Ki = 1548.82 nM 5.81
CHEMBL3314327 — Ki = 2818.38 nM 5.55
CHEMBL3314327 — Ki = 2831.2 nM 5.55
CHEMBL3314324 — Ki = 5164.8 nM 5.29
CHEMBL3314324 — Ki = 5128.61 nM 5.29
CHEMBL3314339 — Ki = 20892.96 nM 4.68
CHEMBL3314339 — Ki = 20662.0 nM 4.68