Assay Detail
Binding
CHEMBL3363357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Tyro3 (unknown origin) by Off-chip Mobility Shift Assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor TYRO3 (CHEMBL5314) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.52 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3326006 | — | — | 1 | 7.77 |
| CHEMBL3326007 | — | — | 1 | 7.77 |
| CHEMBL3326004 | — | — | 1 | 7.48 |
| CHEMBL3326005 | — | — | 1 | 7.35 |
| CHEMBL3326002 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3326006 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3326007 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3326004 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3326005 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3326002 | — | IC50 | = | 60.0 | nM | 7.22 |