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Assay Detail

CHEMBL3363483

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Functional
Antiproliferative activity against human LS 174T cells after 4 days by Vi-Cell cell viability analyzer
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LS174T
Confidence 1 — Organism
Curated By Autocuration

Publication

Halogenated diarylacetylenes repress c-myc expression in cancer cells.
Sviripa VM, Zhang W, Kril LM, Liu AX, Yuan Y, Zhan CG, Liu C, Watt DS.
Bioorg Med Chem Lett (2014) 24 : 3638 -3640
PubMed 24930834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.37 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3309938 1 7.72
CHEMBL3309926 1 7.64
CHEMBL3309937 1 7.64
CHEMBL3309929 1 7.51
CHEMBL3309928 1 7.41
CHEMBL3309939 1 7.28
CHEMBL3309925 1 7.26
CHEMBL3309936 1 7.26
CHEMBL3309933 1 7.25
CHEMBL2153098 1 7.23
CHEMBL3309932 1 6.92
CHEMBL3309931 1 -
CHEMBL3309930 1 -
CHEMBL3309927 1 -
CHEMBL3309934 1 -
CHEMBL3309935 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3309938 IC50 = 19.0 nM 7.72
CHEMBL3309926 IC50 = 23.0 nM 7.64
CHEMBL3309937 IC50 = 23.0 nM 7.64
CHEMBL3309929 IC50 = 31.0 nM 7.51
CHEMBL3309928 IC50 = 39.0 nM 7.41
CHEMBL3309939 IC50 = 52.0 nM 7.28
CHEMBL3309925 IC50 = 55.0 nM 7.26
CHEMBL3309936 IC50 = 55.0 nM 7.26
CHEMBL3309933 IC50 = 56.0 nM 7.25
CHEMBL2153098 IC50 = 59.0 nM 7.23
CHEMBL3309932 IC50 = 119.0 nM 6.92
CHEMBL3309931 IC50 > 3000.0 nM -
CHEMBL3309930 IC50 > 3000.0 nM -
CHEMBL3309927 IC50 > 3000.0 nM -
CHEMBL3309934 IC50 > 3000.0 nM -
CHEMBL3309935 IC50 > 3000.0 nM -