Assay Detail
ADMET
CHEMBL3363902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CYP1A2 preincubated for 5 mins before fluorescent substrate addition by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.95 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592374 | AMITIFADINE | 2.0 | 1 | 6.10 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 5.28 |
| CHEMBL3310485 | — | — | 1 | 4.89 |
| CHEMBL3310483 | — | — | 1 | 4.82 |
| CHEMBL3310486 | — | — | 1 | 4.72 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 4.50 |
| CHEMBL3310484 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592374 | AMITIFADINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1175 | DULOXETINE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3310485 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3310483 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3310486 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3310484 | — | IC50 | = | 44000.0 | nM | 4.36 |