Assay Detail
Functional
CHEMBL3364005
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Antiproliferative activity against wild-type p53 expressing human HCT116 cells assessed as inhibition of cell proliferation by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.17 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310320 | — | — | 1 | 8.10 |
| CHEMBL3310184 | — | — | 1 | 8.00 |
| CHEMBL3310188 | — | — | 1 | 7.70 |
| CHEMBL3310182 | — | — | 1 | 7.30 |
| CHEMBL3310185 | — | — | 1 | 7.16 |
| CHEMBL3310186 | — | — | 1 | 7.10 |
| CHEMBL3310321 | — | — | 1 | 6.92 |
| CHEMBL3310187 | — | — | 1 | 6.92 |
| CHEMBL3310319 | — | — | 1 | 6.75 |
| CHEMBL3310322 | — | — | 1 | 6.75 |
| CHEMBL3310323 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310320 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3310184 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3310188 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3310182 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3310185 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3310186 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3310321 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3310187 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3310319 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3310322 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3310323 | — | IC50 | = | 670.0 | nM | 6.17 |