Assay Detail
Binding
CHEMBL3364064
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Inhibition of amyloid beta1-42 (unknown origin) aggregation assessed as amyloid fibril formation tested after 17 hrs by thioflavin T fluorescence method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Naturally occurring polyphenolic inhibitors of amyloid beta aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.34 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298066 | — | — | 1 | 5.57 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 5.34 |
| CHEMBL3297746 | — | — | 1 | 5.27 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298066 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3297746 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 6400.0 | nM | 5.19 |