Assay Detail
Binding
CHEMBL3364070
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.22 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 9.22 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 8.00 |
| CHEMBL3298512 | — | — | 1 | 6.24 |
| CHEMBL3298516 | — | — | 1 | 5.35 |
| CHEMBL3298929 | — | — | 1 | 5.33 |
| CHEMBL3298792 | — | — | 1 | 4.79 |
| CHEMBL3298611 | — | — | 1 | 4.61 |
| CHEMBL3298513 | — | — | 1 | - |
| CHEMBL3298514 | — | — | 1 | - |
| CHEMBL3298515 | — | — | 1 | - |
| CHEMBL3298610 | — | — | 1 | - |
| CHEMBL3298928 | — | — | 1 | - |
| CHEMBL3358446 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494089 | GSK-690693 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3298512 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3298516 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL3298929 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL3298792 | — | IC50 | = | 16130.0 | nM | 4.79 |
| CHEMBL3298611 | — | IC50 | = | 24660.0 | nM | 4.61 |
| CHEMBL3298513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3298514 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3298515 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3298610 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3298928 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3358446 | — | IC50 | > | 100000.0 | nM | - |