Assay Detail
Functional
CHEMBL3364317
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Inhibition of human TP receptor expressed in QBI-HEK 293A cells assessed as IP3 metabolite level after 1 hr by HTRF assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 293A |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.13 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29374 | — | — | 1 | 8.59 |
| CHEMBL3326602 | — | — | 1 | 7.27 |
| CHEMBL65121 | — | — | 1 | 6.72 |
| CHEMBL3326603 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29374 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3326602 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL65121 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3326603 | — | IC50 | = | 1140.0 | nM | 5.94 |