Assay Detail
Functional
CHEMBL3364356
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Growth inhibition of human HCT116 cells after 72 hrs by coulter counter method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 5.12 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 5.09 |
| CHEMBL3298512 | — | — | 1 | 4.67 |
| CHEMBL3358446 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1079175 | MK-2206 | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3298512 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3358446 | — | IC50 | > | 100000.0 | nM | - |