Assay Detail
ADMET
CHEMBL3364615
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Inhibition of CYP2C19 (unknown origin) using MFC substrate after 30 mins by fluorescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.14 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353342 | — | — | 1 | 6.96 |
| CHEMBL2407749 | — | — | 1 | 6.89 |
| CHEMBL3353337 | — | — | 1 | 6.68 |
| CHEMBL3353340 | — | — | 1 | 6.58 |
| CHEMBL3353346 | — | — | 1 | 6.22 |
| CHEMBL3353348 | — | — | 1 | 6.12 |
| CHEMBL2407900 | — | — | 1 | 6.10 |
| CHEMBL3353356 | — | — | 1 | 6.00 |
| CHEMBL2407897 | — | — | 1 | 6.00 |
| CHEMBL3353341 | — | — | 1 | 5.80 |
| CHEMBL3353354 | — | — | 1 | 5.75 |
| CHEMBL3353355 | — | — | 1 | 5.68 |
| CHEMBL3353338 | — | — | 1 | 5.00 |
| CHEMBL3353359 | — | — | 1 | - |
| CHEMBL3353339 | — | — | 1 | - |
| CHEMBL3353347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353342 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2407749 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3353337 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3353340 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3353346 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3353348 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2407900 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3353356 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2407897 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3353341 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3353354 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3353355 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3353338 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3353359 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3353339 | — | IC50 | - | — | - | |
| CHEMBL3353347 | — | IC50 | > | 1000.0 | nM | - |