Assay Detail
Functional
CHEMBL3364790
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Partial agonist activity at human cannabinoid CB2 receptor expressed in CHO-K1 cells assessed as [S35]GTPgammaS binding by scintillation counting
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
One-pot heterogeneous synthesis of Δ(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.30 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 8.03 |
| CHEMBL3329945 | — | — | 1 | 7.96 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 7.91 |
| CHEMBL3329946 | — | — | 1 | 7.76 |
| CHEMBL3329480 | — | — | 1 | 6.09 |
| CHEMBL3329481 | — | — | 1 | 6.03 |
| CHEMBL3329477 | — | — | 1 | - |
| CHEMBL3329478 | — | — | 1 | - |
| CHEMBL3329479 | — | — | 1 | - |
| CHEMBL3329482 | — | — | 1 | - |
| CHEMBL3329483 | — | — | 1 | - |
| CHEMBL3329943 | — | — | 1 | - |
| CHEMBL3329944 | — | — | 1 | - |
| CHEMBL3329947 | — | — | 1 | - |
| CHEMBL188 | WIN-552122 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3329945 | — | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL465 | DRONABINOL | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3329946 | — | EC50 | = | 17.4 | nM | 7.76 |
| CHEMBL3329480 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3329481 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3329477 | — | EC50 | - | — | - | |
| CHEMBL3329478 | — | EC50 | - | — | - | |
| CHEMBL3329479 | — | EC50 | - | — | - | |
| CHEMBL3329482 | — | EC50 | - | — | - | |
| CHEMBL3329483 | — | EC50 | - | — | - | |
| CHEMBL3329943 | — | EC50 | - | — | - | |
| CHEMBL3329944 | — | EC50 | - | — | - | |
| CHEMBL3329947 | — | EC50 | - | — | - | |
| CHEMBL188 | WIN-552122 | EC50 | - | — | - |