Assay Detail
Binding
CHEMBL3364794
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Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.85 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3321794 | — | — | 1 | 9.15 |
| CHEMBL3321798 | — | — | 1 | 8.57 |
| CHEMBL445334 | — | — | 1 | 8.15 |
| CHEMBL3321778 | — | — | 1 | 7.62 |
| CHEMBL3321777 | — | — | 1 | 7.55 |
| CHEMBL3321795 | — | — | 1 | 7.54 |
| CHEMBL3321793 | — | — | 1 | 7.44 |
| CHEMBL3321796 | — | — | 1 | 7.39 |
| CHEMBL3321797 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3321794 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3321798 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL445334 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL3321778 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3321777 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3321795 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3321793 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL3321796 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3321797 | — | Ki | = | 62.0 | nM | 7.21 |