Assay Detail
Binding
CHEMBL3364869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | L929 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 5 (CHEMBL4306) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.99 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298226 | — | — | 1 | 7.66 |
| CHEMBL3298228 | — | — | 1 | 7.64 |
| CHEMBL3356073 | — | — | 1 | 7.60 |
| CHEMBL3298140 | — | — | 1 | 7.37 |
| CHEMBL3298227 | — | — | 1 | 7.14 |
| CHEMBL3356074 | — | — | 1 | 7.08 |
| CHEMBL3298231 | — | — | 1 | 7.06 |
| CHEMBL3298225 | — | — | 1 | 6.93 |
| CHEMBL3298232 | — | — | 1 | 6.86 |
| CHEMBL3298147 | — | — | 1 | 6.73 |
| CHEMBL3298229 | — | — | 1 | 6.71 |
| CHEMBL3356070 | — | — | 1 | 6.70 |
| CHEMBL3298145 | — | — | 1 | 6.66 |
| CHEMBL3298146 | — | — | 1 | 6.58 |
| CHEMBL3298141 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298226 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3298228 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3356073 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3298140 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3298227 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3356074 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3298231 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3298225 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL3298232 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL3298147 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL3298229 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3356070 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL3298145 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL3298146 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL3298141 | — | IC50 | = | 784.0 | nM | 6.11 |