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Assay Detail

CHEMBL3365043

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones.
Lindgren EB, de Brito MA, Vasconcelos TR, de Moraes MO, Montenegro RC, Yoneda JD, Leal KZ.
Eur J Med Chem (2014) 86 : 12 -16
PubMed 25147145 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.78 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 7.40
CHEMBL3325587 1 6.46
CHEMBL3325588 1 6.23
CHEMBL3325577 1 5.78
CHEMBL3325589 1 5.72
CHEMBL3325590 1 5.34
CHEMBL3194521 1 5.26
CHEMBL3325586 1 4.94
CHEMBL3310964 1 4.87
CHEMBL1973778 1 -
CHEMBL3325578 1 -
CHEMBL3325579 1 -
CHEMBL3325580 1 -
CHEMBL3325581 1 -
CHEMBL3325582 1 -
CHEMBL3325583 1 -
CHEMBL3325584 1 -
CHEMBL3325585 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 40.0 nM 7.40
CHEMBL3325587 IC50 = 350.0 nM 6.46
CHEMBL3325588 IC50 = 590.0 nM 6.23
CHEMBL3325577 IC50 = 1650.0 nM 5.78
CHEMBL3325589 IC50 = 1890.0 nM 5.72
CHEMBL3325590 IC50 = 4600.0 nM 5.34
CHEMBL3194521 IC50 = 5510.0 nM 5.26
CHEMBL3325586 IC50 = 11470.0 nM 4.94
CHEMBL3310964 IC50 = 13600.0 nM 4.87
CHEMBL1973778 IC50 > 16700.0 nM -
CHEMBL3325578 IC50 > 17370.0 nM -
CHEMBL3325579 IC50 > 16870.0 nM -
CHEMBL3325580 IC50 > 16810.0 nM -
CHEMBL3325581 IC50 > 15520.0 nM -
CHEMBL3325582 IC50 > 17280.0 nM -
CHEMBL3325583 IC50 > 17770.0 nM -
CHEMBL3325584 IC50 > 15950.0 nM -
CHEMBL3325585 IC50 > 15050.0 nM -