Assay Detail
Binding
CHEMBL3365197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LYP (unknown origin) using DiFMUP substrate incubated for 2 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 22 (CHEMBL2889) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.60 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52347 | 1,2-NAPHTHOQUINONE | — | 1 | 5.96 |
| CHEMBL204543 | — | — | 1 | 5.60 |
| CHEMBL240963 | LAWSONE | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52347 | 1,2-NAPHTHOQUINONE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL204543 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL240963 | LAWSONE | IC50 | = | 5600.0 | nM | 5.25 |