Assay Detail

CHEMBL3365262

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Induction of dopamine release in rat striatal synaptosomes

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Brain
Subcellular	Synaptosomes
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.

Yu LF, Zhang HK, Caldarone BJ, Eaton JB, Lukas RJ, Kozikowski AP.
J Med Chem (2014) 57 : 8204 -8223
PubMed 24901260 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.97	6.97

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL188462	ISPRONICLINE	2.0	1	6.97

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL188462	ISPRONICLINE	EC50	=	106.0	nM	6.97