Assay Detail
Binding
CHEMBL3365309
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Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Schistosoma mansoni |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Thioredoxin glutathione reductase (CHEMBL6110) ↗| Type | SINGLE PROTEIN |
| Organism | Schistosoma mansoni |
Publication
New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.46 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3322287 | — | — | 1 | 8.00 |
| CHEMBL3322292 | — | — | 1 | 7.08 |
| CHEMBL3322286 | — | — | 1 | 6.83 |
| CHEMBL3322288 | — | — | 1 | 6.50 |
| CHEMBL3322293 | — | — | 1 | 6.46 |
| CHEMBL336467 | FUROXAN | — | 1 | 5.30 |
| CHEMBL3322356 | — | — | 1 | 5.07 |
| CHEMBL3322357 | — | — | 1 | - |
| CHEMBL3322355 | — | — | 1 | - |
| CHEMBL3322294 | — | — | 1 | - |
| CHEMBL3322291 | — | — | 1 | - |
| CHEMBL3322290 | — | — | 1 | - |
| CHEMBL3322289 | — | — | 1 | - |
| CHEMBL976 | PRAZIQUANTEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3322287 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3322292 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3322286 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3322288 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL3322293 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL336467 | FUROXAN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3322356 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3322357 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3322355 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3322294 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3322291 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3322290 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3322289 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL976 | PRAZIQUANTEL | IC50 | - | — | - |