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Assay Detail

CHEMBL3365634

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Functional
Antiproliferative activity against human HMEC1 cells after 72 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HMEC-1
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis of natural-like acylphloroglucinols with anti-proliferative, anti-oxidative and tube-formation inhibitory activity.
Sun Q, Schmidt S, Tremmel M, Heilmann J, König B.
Eur J Med Chem (2014) 85 : 621 -628
PubMed 25128665 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.75 6.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3331174 1 6.06
CHEMBL3331178 1 5.12
CHEMBL3331168 1 5.06
CHEMBL3331100 1 4.96
CHEMBL253896 XANTHOHUMOL 2.0 1 4.94
CHEMBL2152496 1 4.88
CHEMBL3331169 1 4.69
CHEMBL524326 1 4.68
CHEMBL1242095 1 4.65
CHEMBL3331099 1 4.65
CHEMBL3331177 1 4.62
CHEMBL3331175 1 4.59
CHEMBL3331170 1 4.53
CHEMBL3331172 1 4.36
CHEMBL3331171 1 4.32
CHEMBL3331173 1 4.29
CHEMBL3331176 1 4.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3331174 IC50 = 880.0 nM 6.06
CHEMBL3331178 IC50 = 7600.0 nM 5.12
CHEMBL3331168 IC50 = 8700.0 nM 5.06
CHEMBL3331100 IC50 = 11000.0 nM 4.96
CHEMBL253896 XANTHOHUMOL IC50 = 11400.0 nM 4.94
CHEMBL2152496 IC50 = 13300.0 nM 4.88
CHEMBL3331169 IC50 = 20300.0 nM 4.69
CHEMBL524326 IC50 = 21000.0 nM 4.68
CHEMBL1242095 IC50 = 22500.0 nM 4.65
CHEMBL3331099 IC50 = 22400.0 nM 4.65
CHEMBL3331177 IC50 = 23900.0 nM 4.62
CHEMBL3331175 IC50 = 25500.0 nM 4.59
CHEMBL3331170 IC50 = 29300.0 nM 4.53
CHEMBL3331172 IC50 = 43400.0 nM 4.36
CHEMBL3331171 IC50 = 48000.0 nM 4.32
CHEMBL3331173 IC50 = 51500.0 nM 4.29
CHEMBL3331176 IC50 = 53800.0 nM 4.27