Assay Detail
Binding
CHEMBL3366152
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Displacement of [3H] 8-OH-DPAT from human 5-HT1A receptor by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further evaluation of the tropane analogs of haloperidol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.92 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3321792 | — | — | 1 | 8.09 |
| CHEMBL3321791 | — | — | 1 | 7.89 |
| CHEMBL3321790 | — | — | 1 | 7.70 |
| CHEMBL210578 | — | — | 1 | 7.56 |
| CHEMBL1940403 | — | — | 1 | 7.13 |
| CHEMBL3321788 | — | — | 1 | 6.99 |
| CHEMBL3321789 | — | — | 1 | 6.91 |
| CHEMBL1940404 | — | — | 1 | 6.50 |
| CHEMBL1940402 | — | — | 1 | 6.18 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 5.68 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3321792 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL3321791 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3321790 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL210578 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL1940403 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL3321788 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL3321789 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL1940404 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL1940402 | — | Ki | = | 658.0 | nM | 6.18 |
| CHEMBL715 | OLANZAPINE | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 3600.0 | nM | 5.44 |