Assay Detail
Binding
CHEMBL3366155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further evaluation of the tropane analogs of haloperidol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.88 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940404 | — | — | 1 | 7.66 |
| CHEMBL1940403 | — | — | 1 | 7.57 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.28 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.92 |
| CHEMBL1940402 | — | — | 1 | 6.89 |
| CHEMBL3321790 | — | — | 1 | 6.46 |
| CHEMBL3321792 | — | — | 1 | 5.39 |
| CHEMBL210578 | — | — | 1 | - |
| CHEMBL3321788 | — | — | 1 | - |
| CHEMBL3321789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940404 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1940403 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL715 | OLANZAPINE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1940402 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3321790 | — | Ki | = | 347.0 | nM | 6.46 |
| CHEMBL3321792 | — | Ki | = | 4093.0 | nM | 5.39 |
| CHEMBL210578 | — | Ki | - | — | - | |
| CHEMBL3321788 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3321789 | — | Ki | > | 10000.0 | nM | - |