Assay Detail
Binding
CHEMBL3366161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Mesulergine from rat 5-HT2C receptor by liquid scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further evaluation of the tropane analogs of haloperidol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.75 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210578 | — | — | 1 | 6.06 |
| CHEMBL3321792 | — | — | 1 | 5.95 |
| CHEMBL3321790 | — | — | 1 | 5.82 |
| CHEMBL3321791 | — | — | 1 | 5.73 |
| CHEMBL3321788 | — | — | 1 | 5.61 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.33 |
| CHEMBL1940404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210578 | — | Ki | = | 872.0 | nM | 6.06 |
| CHEMBL3321792 | — | Ki | = | 1122.0 | nM | 5.95 |
| CHEMBL3321790 | — | Ki | = | 1498.0 | nM | 5.82 |
| CHEMBL3321791 | — | Ki | = | 1861.0 | nM | 5.73 |
| CHEMBL3321788 | — | Ki | = | 2434.0 | nM | 5.61 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL1940404 | — | Ki | > | 10000.0 | nM | - |