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Assay Detail

CHEMBL3366246

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Functional
Antiproliferative activity against human PC3 cells after 72 hrs
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 1 — Organism
Curated By Autocuration

Publication

2-Phenylaminonaphthoquinones and related compounds: synthesis, trypanocidal and cytotoxic activities.
Sieveking I, Thomas P, Estévez JC, Quiñones N, Cuéllar MA, Villena J, Espinosa-Bustos C, Fierro A, Tapia RA, Maya JD, López-Muñoz R, Cassels BK, Estévez RJ, Salas CO.
Bioorg Med Chem (2014) 22 : 4609 -4620
PubMed 25127463 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.25 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3331093 1 6.28
CHEMBL53463 DOXORUBICIN 4.0 1 6.27
CHEMBL1631462 1 5.99
CHEMBL3331078 1 4.98
CHEMBL3331082 1 4.55
CHEMBL1631460 1 4.45
CHEMBL3331079 1 4.22
CHEMBL3331076 1 -
CHEMBL3331077 1 -
CHEMBL3331080 1 -
CHEMBL3331084 1 -
CHEMBL3331086 1 -
CHEMBL3331091 1 -
CHEMBL3331092 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3331093 IC50 = 530.0 nM 6.28
CHEMBL53463 DOXORUBICIN IC50 = 540.0 nM 6.27
CHEMBL1631462 IC50 = 1030.0 nM 5.99
CHEMBL3331078 IC50 = 10400.0 nM 4.98
CHEMBL3331082 IC50 = 27900.0 nM 4.55
CHEMBL1631460 IC50 = 35400.0 nM 4.45
CHEMBL3331079 IC50 = 60000.0 nM 4.22
CHEMBL3331076 IC50 > 100000.0 nM -
CHEMBL3331077 IC50 > 100000.0 nM -
CHEMBL3331080 IC50 > 100000.0 nM -
CHEMBL3331084 IC50 > 100000.0 nM -
CHEMBL3331086 IC50 > 100000.0 nM -
CHEMBL3331091 IC50 > 100000.0 nM -
CHEMBL3331092 IC50 > 100000.0 nM -