Assay Detail
Binding
CHEMBL3366593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC4 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.84 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.47 |
| CHEMBL3310510 | — | — | 1 | 4.20 |
| CHEMBL3310506 | — | — | 1 | - |
| CHEMBL3310507 | — | — | 1 | - |
| CHEMBL3310508 | — | — | 1 | - |
| CHEMBL3310509 | — | — | 1 | - |
| CHEMBL3310511 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3310510 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL3310506 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3310507 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3310508 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3310509 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3310511 | — | IC50 | > | 100000.0 | nM | - |