Assay Detail
Binding
CHEMBL3366599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse HDAC6 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreitol
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.52 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.20 |
| CHEMBL3310510 | — | — | 1 | 7.08 |
| CHEMBL3310509 | — | — | 1 | 6.50 |
| CHEMBL3310511 | — | — | 1 | 6.23 |
| CHEMBL3310506 | — | — | 1 | 5.89 |
| CHEMBL3310508 | — | — | 1 | 5.63 |
| CHEMBL3310507 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 0.625 | nM | 9.20 |
| CHEMBL3310510 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3310509 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3310511 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3310506 | — | IC50 | = | 1301.0 | nM | 5.89 |
| CHEMBL3310508 | — | IC50 | = | 2319.0 | nM | 5.63 |
| CHEMBL3310507 | — | IC50 | = | 7300.0 | nM | 5.14 |