Assay Detail
Binding
CHEMBL3366740
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Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins before substrate addition by Ellman method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.19 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | — | 1 | 9.15 |
| CHEMBL3355579 | — | — | 1 | 8.17 |
| CHEMBL3355580 | — | — | 1 | 7.74 |
| CHEMBL3355581 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3355579 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL3355580 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL3355581 | — | IC50 | = | 21.1 | nM | 7.68 |