Assay Detail
Functional
CHEMBL3366751
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Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of viral p24 antigen production by ELISA
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.14 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3341856 | — | — | 1 | 8.66 |
| CHEMBL3341857 | — | — | 1 | 8.51 |
| CHEMBL3341854 | — | — | 1 | 8.37 |
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 7.96 |
| CHEMBL3341855 | — | — | 1 | 7.38 |
| CHEMBL3341853 | — | — | 1 | 7.21 |
| CHEMBL3341849 | — | — | 1 | 7.03 |
| CHEMBL3341847 | — | — | 1 | 6.88 |
| CHEMBL3341852 | — | — | 1 | 6.81 |
| CHEMBL3341850 | — | — | 1 | 6.62 |
| CHEMBL3341846 | — | — | 1 | 6.43 |
| CHEMBL3341848 | — | — | 1 | 6.41 |
| CHEMBL3341844 | — | — | 1 | 6.32 |
| CHEMBL3341851 | — | — | 1 | 6.30 |
| CHEMBL3341845 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3341856 | — | EC50 | = | 2.18 | nM | 8.66 |
| CHEMBL3341857 | — | EC50 | = | 3.11 | nM | 8.51 |
| CHEMBL3341854 | — | EC50 | = | 4.28 | nM | 8.37 |
| CHEMBL525076 | ENFUVIRTIDE | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL3341855 | — | EC50 | = | 41.4 | nM | 7.38 |
| CHEMBL3341853 | — | EC50 | = | 61.6 | nM | 7.21 |
| CHEMBL3341849 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3341847 | — | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3341852 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL3341850 | — | EC50 | = | 242.0 | nM | 6.62 |
| CHEMBL3341846 | — | EC50 | = | 369.0 | nM | 6.43 |
| CHEMBL3341848 | — | EC50 | = | 387.0 | nM | 6.41 |
| CHEMBL3341844 | — | EC50 | = | 475.0 | nM | 6.32 |
| CHEMBL3341851 | — | EC50 | = | 501.0 | nM | 6.30 |
| CHEMBL3341845 | — | EC50 | = | 565.0 | nM | 6.25 |