Assay Detail
Functional
CHEMBL3366753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 BaL infected in human MT2 cells assessed as inhibition of viral replication
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.32 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3341857 | — | — | 1 | 9.57 |
| CHEMBL3341856 | — | — | 1 | 8.60 |
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 8.54 |
| CHEMBL3341854 | — | — | 1 | 8.16 |
| CHEMBL3341855 | — | — | 1 | 7.68 |
| CHEMBL3341853 | — | — | 1 | 7.08 |
| CHEMBL3341847 | — | — | 1 | 7.01 |
| CHEMBL3341851 | — | — | 1 | 7.00 |
| CHEMBL3341848 | — | — | 1 | 6.95 |
| CHEMBL3341852 | — | — | 1 | 6.87 |
| CHEMBL3341849 | — | — | 1 | 6.82 |
| CHEMBL3341845 | — | — | 1 | 6.54 |
| CHEMBL3341844 | — | — | 1 | 6.34 |
| CHEMBL3341846 | — | — | 1 | 6.30 |
| CHEMBL3341850 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3341857 | — | EC50 | = | 0.271 | nM | 9.57 |
| CHEMBL3341856 | — | EC50 | = | 2.51 | nM | 8.60 |
| CHEMBL525076 | ENFUVIRTIDE | EC50 | = | 2.88 | nM | 8.54 |
| CHEMBL3341854 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3341855 | — | EC50 | = | 20.8 | nM | 7.68 |
| CHEMBL3341853 | — | EC50 | = | 83.1 | nM | 7.08 |
| CHEMBL3341847 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3341851 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3341848 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3341852 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL3341849 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3341845 | — | EC50 | = | 288.0 | nM | 6.54 |
| CHEMBL3341844 | — | EC50 | = | 456.0 | nM | 6.34 |
| CHEMBL3341846 | — | EC50 | = | 498.0 | nM | 6.30 |
| CHEMBL3341850 | — | EC50 | = | 519.0 | nM | 6.29 |