Assay Detail
Binding
CHEMBL3366758
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Inhibition of HIV1 gp41 NHR assessed as inhibition of 6HB formation by FRET assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.15 | 5.55 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2380932 | — | — | 1 | 5.55 |
| CHEMBL3341852 | — | — | 1 | 5.08 |
| CHEMBL3341853 | — | — | 1 | 5.08 |
| CHEMBL3341854 | — | — | 1 | 5.08 |
| CHEMBL3341855 | — | — | 1 | 5.08 |
| CHEMBL3341856 | — | — | 1 | 5.08 |
| CHEMBL3341857 | — | — | 1 | 5.08 |
| CHEMBL3341859 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2380932 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL3341852 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL3341853 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL3341854 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL3341855 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL3341856 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL3341857 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL3341859 | — | Inhibition | - | % | - |