Assay Detail
Binding
CHEMBL3367171
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Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule inhibitors targeting activator protein 1 (AP-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.33 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337665 | — | — | 1 | 8.52 |
| CHEMBL129857 | AS-602868 | 1.0 | 1 | 8.10 |
| CHEMBL43549 | — | — | 1 | 7.70 |
| CHEMBL132495 | — | — | 1 | 7.70 |
| CHEMBL85822 | — | — | 1 | 7.46 |
| CHEMBL86615 | — | — | 1 | 7.35 |
| CHEMBL336546 | — | — | 1 | 7.30 |
| CHEMBL315804 | — | — | 1 | 7.01 |
| CHEMBL3341912 | — | — | 1 | 7.00 |
| CHEMBL42952 | — | — | 1 | 7.00 |
| CHEMBL131006 | — | — | 1 | 7.00 |
| CHEMBL340779 | — | — | 1 | 6.70 |
| CHEMBL87274 | — | — | 1 | 6.68 |
| CHEMBL87433 | — | — | 1 | 6.52 |
| CHEMBL423150 | — | — | 1 | 6.40 |
| CHEMBL83026 | — | — | 1 | 6.40 |
| CHEMBL3341901 | — | — | 1 | 6.30 |
| CHEMBL3341914 | — | — | 1 | 6.12 |
| CHEMBL3341913 | — | — | 1 | 6.08 |
| CHEMBL42719 | — | — | 1 | 6.00 |
| CHEMBL338934 | — | — | 1 | 5.77 |
| CHEMBL3341911 | — | — | 1 | 5.72 |
| CHEMBL87572 | — | — | 1 | 5.70 |
| CHEMBL340410 | — | — | 1 | 5.40 |
| CHEMBL88100 | — | — | 1 | 5.36 |
| CHEMBL3341908 | — | — | 1 | 5.21 |
| CHEMBL3341909 | — | — | 1 | 5.07 |
| CHEMBL3341906 | — | — | 1 | 5.03 |
| CHEMBL3341907 | — | — | 1 | 5.03 |
| CHEMBL128708 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337665 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL129857 | AS-602868 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL132495 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL43549 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL85822 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL86615 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL336546 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL315804 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL131006 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL42952 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3341912 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL340779 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL87274 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL87433 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL83026 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL423150 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3341901 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3341914 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3341913 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL42719 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL338934 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3341911 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL87572 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL340410 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL88100 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3341908 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3341909 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3341907 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3341906 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL128708 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3341905 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3341910 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL132457 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3341903 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3341902 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL128808 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL128314 | — | IC50 | > | 10000.0 | nM | - |