Assay Detail
Binding
CHEMBL3367286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of goat liver cathepsin B using BANA substrate pre-incubated 30 mins before substrate addition by colorimetry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Capra hircus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3309619 | — | — | 1 | 6.35 |
| CHEMBL3309796 | — | — | 1 | 6.30 |
| CHEMBL3309801 | — | — | 1 | 6.13 |
| CHEMBL3309806 | — | — | 1 | 5.25 |
| CHEMBL3309798 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3309619 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3309796 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3309801 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3309806 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL3309798 | — | IC50 | = | 5900.0 | nM | 5.23 |