Assay Detail
Binding
CHEMBL3367288
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Competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Capra hircus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.27 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3309619 | — | — | 1 | 7.38 |
| CHEMBL3309796 | — | — | 1 | 7.28 |
| CHEMBL3309801 | — | — | 1 | 6.88 |
| CHEMBL3309806 | — | — | 1 | 5.88 |
| CHEMBL2132758 | — | — | 1 | 5.88 |
| CHEMBL2130993 | — | — | 1 | 5.87 |
| CHEMBL3309795 | — | — | 1 | 5.54 |
| CHEMBL3309794 | — | — | 1 | 5.50 |
| CHEMBL3309617 | — | — | 1 | 5.48 |
| CHEMBL3309618 | — | — | 1 | 5.41 |
| CHEMBL3309807 | — | — | 1 | 5.33 |
| CHEMBL3309267 | — | — | 1 | 5.11 |
| CHEMBL2143048 | — | — | 1 | 5.00 |
| CHEMBL3309797 | — | — | 1 | 4.89 |
| CHEMBL3309616 | — | — | 1 | 4.89 |
| CHEMBL3309800 | — | — | 1 | 4.83 |
| CHEMBL3309804 | — | — | 1 | 4.75 |
| CHEMBL3309799 | — | — | 1 | 4.42 |
| CHEMBL1684781 | — | — | 1 | 4.40 |
| CHEMBL3309805 | — | — | 1 | 4.28 |
| CHEMBL3309803 | — | — | 1 | 4.13 |
| CHEMBL2137785 | — | — | 1 | 4.10 |
| CHEMBL2136015 | — | — | 1 | 4.04 |
| CHEMBL3309802 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3309619 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL3309796 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL3309801 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL3309806 | — | Ki | = | 1311.0 | nM | 5.88 |
| CHEMBL2132758 | — | Ki | = | 1311.0 | nM | 5.88 |
| CHEMBL2130993 | — | Ki | = | 1365.0 | nM | 5.87 |
| CHEMBL3309795 | — | Ki | = | 2888.0 | nM | 5.54 |
| CHEMBL3309794 | — | Ki | = | 3150.0 | nM | 5.50 |
| CHEMBL3309617 | — | Ki | = | 3280.0 | nM | 5.48 |
| CHEMBL3309618 | — | Ki | = | 3883.0 | nM | 5.41 |
| CHEMBL3309807 | — | Ki | = | 4706.0 | nM | 5.33 |
| CHEMBL3309267 | — | Ki | = | 7843.0 | nM | 5.11 |
| CHEMBL2143048 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL3309797 | — | Ki | = | 12740.0 | nM | 4.89 |
| CHEMBL3309616 | — | Ki | = | 12740.0 | nM | 4.89 |
| CHEMBL3309800 | — | Ki | = | 14810.0 | nM | 4.83 |
| CHEMBL3309804 | — | Ki | = | 17800.0 | nM | 4.75 |
| CHEMBL3309799 | — | Ki | = | 38090.0 | nM | 4.42 |
| CHEMBL1684781 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL3309805 | — | Ki | = | 52600.0 | nM | 4.28 |
| CHEMBL3309803 | — | Ki | = | 74070.0 | nM | 4.13 |
| CHEMBL2137785 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL2136015 | — | Ki | = | 90900.0 | nM | 4.04 |
| CHEMBL3309802 | — | Ki | = | 114300.0 | nM | - |