Assay Detail
Functional
CHEMBL3367487
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Cytotoxicity against human HuCCa1 cells after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HuCC-A1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.14 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.62 |
| CHEMBL3322529 | — | — | 1 | 5.63 |
| CHEMBL3322530 | — | — | 1 | 5.48 |
| CHEMBL1631465 | — | — | 1 | 5.28 |
| CHEMBL3322527 | — | — | 1 | 5.10 |
| CHEMBL155563 | — | — | 1 | 5.06 |
| CHEMBL3322521 | — | — | 1 | 4.97 |
| CHEMBL318782 | Dichlon | — | 1 | 4.72 |
| CHEMBL3322528 | — | — | 1 | 4.30 |
| CHEMBL3322526 | — | — | 1 | 4.21 |
| CHEMBL3322531 | — | — | 1 | - |
| CHEMBL1723955 | — | — | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL3322529 | — | IC50 | = | 2364.0 | nM | 5.63 |
| CHEMBL3322530 | — | IC50 | = | 3285.0 | nM | 5.48 |
| CHEMBL1631465 | — | IC50 | = | 5206.0 | nM | 5.28 |
| CHEMBL3322527 | — | IC50 | = | 7916.0 | nM | 5.10 |
| CHEMBL155563 | — | IC50 | = | 8636.0 | nM | 5.06 |
| CHEMBL3322521 | — | IC50 | = | 10672.0 | nM | 4.97 |
| CHEMBL318782 | Dichlon | IC50 | = | 19204.0 | nM | 4.72 |
| CHEMBL3322528 | — | IC50 | = | 50134.0 | nM | 4.30 |
| CHEMBL3322526 | — | IC50 | = | 61163.0 | nM | 4.21 |
| CHEMBL3322531 | — | IC50 | - | — | - | |
| CHEMBL1723955 | — | IC50 | - | — | - | |
| CHEMBL44657 | ETOPOSIDE | IC50 | - | — | - |