Assay Detail
Binding
CHEMBL3367574
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Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
'Carba'-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.22 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290429 | CARFENTANIL | 2.0 | 1 | 10.62 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.84 |
| CHEMBL3325854 | — | — | 1 | 7.02 |
| CHEMBL1091995 | — | — | 1 | 6.38 |
| CHEMBL3325853 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290429 | CARFENTANIL | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL70 | MORPHINE | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL3325854 | — | Ki | = | 95.2 | nM | 7.02 |
| CHEMBL1091995 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL3325853 | — | Ki | > | 5000.0 | nM | - |