Assay Detail
Binding
CHEMBL3367579
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Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
'Carba'-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ke | 2 | - | - |
| IC50 | 2 | 9.13 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290429 | CARFENTANIL | 2.0 | 1 | 10.72 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.53 |
| CHEMBL3325853 | — | — | 1 | - |
| CHEMBL1091995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290429 | CARFENTANIL | IC50 | = | 0.019 | nM | 10.72 |
| CHEMBL70 | MORPHINE | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL3325853 | — | Ke | = | 4050.0 | nM | - |
| CHEMBL1091995 | — | Ke | = | 1240.0 | nM | - |