Assay Detail
Binding
CHEMBL3367639
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Inhibition of AChE (unknown origin) using ACh chloride as substrate preincubated for 15 mins before substrate addition by Ellman method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.81 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 5.62 |
| CHEMBL3310703 | — | — | 1 | 5.60 |
| CHEMBL3360758 | — | — | 1 | 5.20 |
| CHEMBL3310705 | — | — | 1 | 4.92 |
| CHEMBL3310704 | — | — | 1 | 4.84 |
| CHEMBL3360757 | — | — | 1 | 4.45 |
| CHEMBL3310706 | — | — | 1 | 4.33 |
| CHEMBL3310697 | — | — | 1 | 4.18 |
| CHEMBL3310699 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3310703 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3360758 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3310705 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3310704 | — | IC50 | = | 14350.0 | nM | 4.84 |
| CHEMBL3360757 | — | IC50 | = | 35120.0 | nM | 4.45 |
| CHEMBL3310706 | — | IC50 | = | 46760.0 | nM | 4.33 |
| CHEMBL3310697 | — | IC50 | = | 65320.0 | nM | 4.18 |
| CHEMBL3310699 | — | IC50 | = | 75350.0 | nM | 4.12 |