Assay Detail
Binding
CHEMBL3367869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium channel subfamily K member 9 (CHEMBL2321614) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.08 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3187482 | — | — | 1 | 7.42 |
| CHEMBL3182449 | — | — | 1 | 6.60 |
| CHEMBL1310568 | — | — | 1 | 6.16 |
| CHEMBL3182359 | — | — | 1 | 6.15 |
| CHEMBL1081188 | — | — | 1 | 6.00 |
| CHEMBL3182725 | — | — | 1 | 6.00 |
| CHEMBL3183773 | — | — | 1 | 5.41 |
| CHEMBL3187891 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3187482 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3182449 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1310568 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3182359 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1081188 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3182725 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3183773 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL3187891 | — | IC50 | = | 12500.0 | nM | 4.90 |