Assay Detail
Functional
CHEMBL3368032
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Cytotoxicity against human PC3 cells after 24 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Click chemistry inspired synthesis and bioevaluation of novel triazolyl derivatives of osthol as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.56 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 4.91 |
| CHEMBL3319102 | — | — | 1 | 4.85 |
| CHEMBL3319122 | — | — | 1 | 4.62 |
| CHEMBL52229 | OSTHOLE | — | 1 | 4.61 |
| CHEMBL3319099 | — | — | 1 | 4.58 |
| CHEMBL3319104 | — | — | 1 | 4.55 |
| CHEMBL3319103 | — | — | 1 | 4.50 |
| CHEMBL3319094 | — | — | 1 | 4.46 |
| CHEMBL3319100 | — | — | 1 | 4.44 |
| CHEMBL3319121 | — | — | 1 | 4.44 |
| CHEMBL3319125 | — | — | 1 | 4.38 |
| CHEMBL3319124 | — | — | 1 | 4.34 |
| CHEMBL3319098 | — | — | 1 | - |
| CHEMBL3319101 | — | — | 1 | - |
| CHEMBL3319097 | — | — | 1 | - |
| CHEMBL3319096 | — | — | 1 | - |
| CHEMBL3319105 | — | — | 1 | - |
| CHEMBL3319106 | — | — | 1 | - |
| CHEMBL3319119 | — | — | 1 | - |
| CHEMBL3319120 | — | — | 1 | - |
| CHEMBL3319095 | — | — | 1 | - |
| CHEMBL3319123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL3319102 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3319122 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL52229 | OSTHOLE | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL3319099 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL3319104 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL3319103 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3319094 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3319100 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL3319121 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL3319125 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL3319124 | — | IC50 | = | 45500.0 | nM | 4.34 |
| CHEMBL3319098 | — | IC50 | - | — | - | |
| CHEMBL3319101 | — | IC50 | - | — | - | |
| CHEMBL3319097 | — | IC50 | - | — | - | |
| CHEMBL3319096 | — | IC50 | - | — | - | |
| CHEMBL3319105 | — | IC50 | - | — | - | |
| CHEMBL3319106 | — | IC50 | - | — | - | |
| CHEMBL3319119 | — | IC50 | - | — | - | |
| CHEMBL3319120 | — | IC50 | - | — | - | |
| CHEMBL3319095 | — | IC50 | - | — | - | |
| CHEMBL3319123 | — | IC50 | - | — | - |