Assay Detail
Functional
CHEMBL3368043
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Cytotoxicity against human Caco2 cells after 24 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.93 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359598 | — | — | 1 | 6.98 |
| CHEMBL77305 | RUBITECAN | 3.0 | 1 | 6.95 |
| CHEMBL1607 | TOPOTECAN HYDROCHLORIDE | 4.0 | 1 | 6.92 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359598 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL77305 | RUBITECAN | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1607 | TOPOTECAN HYDROCHLORIDE | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 131.0 | nM | 6.88 |