Assay Detail
Functional
CHEMBL3368044
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Cytotoxicity against human A375 cells after 24 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.78 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77305 | RUBITECAN | 3.0 | 1 | 6.86 |
| CHEMBL1607 | TOPOTECAN HYDROCHLORIDE | 4.0 | 1 | 6.79 |
| CHEMBL3359598 | — | — | 1 | 6.73 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77305 | RUBITECAN | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL1607 | TOPOTECAN HYDROCHLORIDE | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL3359598 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 187.0 | nM | 6.73 |