Assay Detail
Functional
CHEMBL3368300
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Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.41 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3321774 | — | — | 1 | 5.72 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.70 |
| CHEMBL3323419 | — | — | 1 | 5.66 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 5.59 |
| CHEMBL3323436 | — | — | 1 | 5.51 |
| CHEMBL3323429 | — | — | 1 | 5.47 |
| CHEMBL3323437 | — | — | 1 | 5.45 |
| CHEMBL3323426 | — | — | 1 | 5.42 |
| CHEMBL3323425 | — | — | 1 | 5.40 |
| CHEMBL3323435 | — | — | 1 | 5.31 |
| CHEMBL3323420 | — | — | 1 | 5.30 |
| CHEMBL3323424 | — | — | 1 | 5.29 |
| CHEMBL3323428 | — | — | 1 | 5.29 |
| CHEMBL3323431 | — | — | 1 | 5.23 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.11 |
| CHEMBL3323432 | — | — | 1 | 5.08 |
| CHEMBL3323427 | — | — | 1 | - |
| CHEMBL3323423 | — | — | 1 | - |
| CHEMBL3323430 | — | — | 1 | - |
| CHEMBL3323433 | — | — | 1 | - |
| CHEMBL3323434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3321774 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL3323419 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL3323436 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL3323429 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL3323437 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL3323426 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL3323425 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL3323435 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL3323420 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL3323424 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL3323428 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL3323431 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL3323432 | — | IC50 | = | 8240.0 | nM | 5.08 |
| CHEMBL3323427 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3323423 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3323430 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3323433 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3323434 | — | IC50 | > | 50000.0 | nM | - |