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Assay Detail

CHEMBL3368560

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Functional
Anticancer activity against human EC9706 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type EC9706
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and anticancer activities of novel 1,2,4-triazolo[3,4-a]phthalazine derivatives.
Xue DQ, Zhang XY, Wang CJ, Ma LY, Zhu N, He P, Shao KP, Chen PJ, Gu YF, Zhang XS, Wang CF, Ji CH, Zhang QR, Liu HM.
Eur J Med Chem (2014) 85 : 235 -244
PubMed 25086915 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.52 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3330922 1 5.70
CHEMBL185 FLUOROURACIL 4.0 1 5.33
CHEMBL3113524 1 5.02
CHEMBL3330767 1 4.92
CHEMBL3330763 1 4.65
CHEMBL3330926 1 4.51
CHEMBL13408 1 4.43
CHEMBL3330924 1 4.37
CHEMBL3330923 1 4.36
CHEMBL3330765 1 4.36
CHEMBL3330762 1 4.33
CHEMBL3330927 1 4.26
CHEMBL3330759 1 4.21
CHEMBL3330764 1 4.17
CHEMBL3330755 1 4.17
CHEMBL3330766 1 4.09
CHEMBL3330925 1 4.04
CHEMBL3330761 1 -
CHEMBL3330760 1 -
CHEMBL3330758 1 -
CHEMBL3330921 1 -
CHEMBL3330757 1 -
CHEMBL3330756 1 -
CHEMBL3113529 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3330922 IC50 = 2000.0 nM 5.70
CHEMBL185 FLUOROURACIL IC50 = 4700.0 nM 5.33
CHEMBL3113524 IC50 = 9500.0 nM 5.02
CHEMBL3330767 IC50 = 11900.0 nM 4.92
CHEMBL3330763 IC50 = 22400.0 nM 4.65
CHEMBL3330926 IC50 = 31200.0 nM 4.51
CHEMBL13408 IC50 = 37200.0 nM 4.43
CHEMBL3330924 IC50 = 42500.0 nM 4.37
CHEMBL3330923 IC50 = 43300.0 nM 4.36
CHEMBL3330765 IC50 = 43800.0 nM 4.36
CHEMBL3330762 IC50 = 46200.0 nM 4.33
CHEMBL3330927 IC50 = 54300.0 nM 4.26
CHEMBL3330759 IC50 = 61300.0 nM 4.21
CHEMBL3330764 IC50 = 67700.0 nM 4.17
CHEMBL3330755 IC50 = 66900.0 nM 4.17
CHEMBL3330766 IC50 = 81700.0 nM 4.09
CHEMBL3330925 IC50 = 91100.0 nM 4.04
CHEMBL3330761 IC50 > 128000.0 nM -
CHEMBL3330760 IC50 > 128000.0 nM -
CHEMBL3330758 IC50 > 128000.0 nM -
CHEMBL3330921 IC50 > 128000.0 nM -
CHEMBL3330757 IC50 > 128000.0 nM -
CHEMBL3330756 IC50 > 128000.0 nM -
CHEMBL3113529 IC50 > 128000.0 nM -