Assay Detail
Functional
CHEMBL3368691
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Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxicity of synthesized 1,4-naphthoquinone analogues on selected human cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.85 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.00 |
| CHEMBL440047 | — | — | 1 | 5.28 |
| CHEMBL239661 | 8-CHLORO-5-HYDROXY-6-METHYLNAPHTHALENE-1,4-DIONE | — | 1 | 5.00 |
| CHEMBL241784 | 5-FLUORO-8-HYDROXY-6-METHYLNAPHTHALENE-1,4-DIONE | — | 1 | 4.99 |
| CHEMBL238593 | 5-BROMO-8-HYDROXY-6-METHYLNAPHTHALENE-1,4-DIONE | — | 1 | 4.95 |
| CHEMBL238592 | 5-CHLORO-8-HYDROXY-6-METHYLNAPHTHALENE-1,4-DIONE | — | 1 | 4.87 |
| CHEMBL239662 | — | — | 1 | 4.79 |
| CHEMBL239663 | — | — | 1 | 4.76 |
| CHEMBL241163 | — | — | 1 | 4.72 |
| CHEMBL241373 | — | — | 1 | 4.72 |
| CHEMBL239879 | — | — | 1 | 4.68 |
| CHEMBL394988 | — | — | 1 | 4.66 |
| CHEMBL241583 | — | — | 1 | 4.65 |
| CHEMBL239878 | — | — | 1 | 4.58 |
| CHEMBL240312 | — | — | 1 | 4.55 |
| CHEMBL241372 | — | — | 1 | 4.53 |
| CHEMBL241243 | — | — | 1 | 4.48 |
| CHEMBL392193 | — | — | 1 | 4.38 |
| CHEMBL393465 | — | — | 1 | 4.28 |
| CHEMBL430853 | RAMENTACEONE | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL440047 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL239661 | 8-CHLORO-5-HYDROXY-6-METHYLNAPHTHALENE-1,4-DIONE | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL241784 | 5-FLUORO-8-HYDROXY-6-METHYLNAPHTHALENE-1,4-DIONE | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL238593 | 5-BROMO-8-HYDROXY-6-METHYLNAPHTHALENE-1,4-DIONE | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL238592 | 5-CHLORO-8-HYDROXY-6-METHYLNAPHTHALENE-1,4-DIONE | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL239662 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL239663 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL241163 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL241373 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL239879 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL394988 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL241583 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL239878 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL240312 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL241372 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL241243 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL392193 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL393465 | — | IC50 | = | 52900.0 | nM | 4.28 |
| CHEMBL430853 | RAMENTACEONE | IC50 | = | 66600.0 | nM | 4.18 |