Assay Detail
Binding
CHEMBL3369280
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Competitive inhibition of human GSTA1 activity by double reciprocal Lineweaver-Burk graph
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,2'-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.11 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310888 | — | — | 1 | 6.44 |
| CHEMBL3310887 | — | — | 1 | 6.42 |
| CHEMBL3310886 | — | — | 1 | 5.83 |
| CHEMBL3310889 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310888 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL3310887 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL3310886 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL3310889 | — | Ki | = | 1750.0 | nM | 5.76 |