Assay Detail
Binding
CHEMBL3369303
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Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M3 receptor in submandibular gland
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Submandibular gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL320) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 9.53 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298595 | — | — | 1 | 10.70 |
| CHEMBL3298599 | — | — | 1 | 10.31 |
| CHEMBL3298588 | — | — | 1 | 10.25 |
| CHEMBL3298596 | — | — | 1 | 10.19 |
| CHEMBL3298600 | — | — | 1 | 10.00 |
| CHEMBL3298763 | — | — | 1 | 9.92 |
| CHEMBL3298333 | — | — | 1 | 9.92 |
| CHEMBL1779047 | — | — | 1 | 9.85 |
| CHEMBL1908368 | — | — | 1 | 9.74 |
| CHEMBL3298589 | — | — | 1 | 9.72 |
| CHEMBL3298591 | — | — | 1 | 9.70 |
| CHEMBL3298334 | — | — | 1 | 9.68 |
| CHEMBL3298598 | — | — | 1 | 9.60 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 9.52 |
| CHEMBL3298597 | — | — | 1 | 9.43 |
| CHEMBL3298592 | — | — | 1 | 9.03 |
| CHEMBL3298601 | — | — | 1 | 8.74 |
| CHEMBL3298590 | — | — | 1 | 8.40 |
| CHEMBL3298594 | — | — | 1 | 8.01 |
| CHEMBL3298593 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298595 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL3298599 | — | Ki | = | 0.049 | nM | 10.31 |
| CHEMBL3298588 | — | Ki | = | 0.056 | nM | 10.25 |
| CHEMBL3298596 | — | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL3298600 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3298763 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL3298333 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL1779047 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL1908368 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL3298589 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL3298591 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3298334 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL3298598 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3298597 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL3298592 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL3298601 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL3298590 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3298594 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL3298593 | — | Ki | = | 12.0 | nM | 7.92 |