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Assay Detail

CHEMBL3369412

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rabbit muscle glycogen phosphorylase a assessed as inhibition of release of phosphate from glucose-1-phosphate after 30 mins by spectrophotometry
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen phosphorylase, muscle form (CHEMBL4696)
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Synthesis, screening and docking of small heterocycles as glycogen phosphorylase inhibitors.
Schweiker SS, Loughlin WA, Lohning AS, Petersson MJ, Jenkins ID.
Eur J Med Chem (2014) 84 : 584 -594
PubMed 25062009 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.70 8.15
Activity 3 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3323454 1 8.15
CHEMBL3323453 1 7.35
CHEMBL3323442 1 4.60
CHEMBL3323438 1 -
CHEMBL3323440 1 -
CHEMBL3323443 1 -
CHEMBL3323444 1 -
CHEMBL1870825 1 -
CHEMBL3323445 1 -
CHEMBL3323446 1 -
CHEMBL3323450 1 -
CHEMBL113 CAFFEINE 4.0 1 -
CHEMBL3323447 1 -
CHEMBL3323421 1 -
CHEMBL3323422 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3323454 IC50 = 7.0 nM 8.15
CHEMBL3323453 IC50 = 45.0 nM 7.35
CHEMBL3323442 IC50 = 25000.0 nM 4.60
CHEMBL3323438 IC50 = 23900000.0 nM -
CHEMBL3323440 IC50 = 1400000.0 nM -
CHEMBL3323443 IC50 = 1100000.0 nM -
CHEMBL3323444 IC50 = 7200000.0 nM -
CHEMBL1870825 IC50 = 1200000.0 nM -
CHEMBL3323445 IC50 = 3000000.0 nM -
CHEMBL3323446 IC50 = 7800000.0 nM -
CHEMBL3323450 IC50 = 6500000.0 nM -
CHEMBL113 CAFFEINE IC50 = 648000.0 nM -
CHEMBL3323447 Activity - -
CHEMBL3323421 Activity - -
CHEMBL3323422 Activity - -